Des duets with singer Susan Anton and asks Dudley Moore about life as a Hollywood film star, before they all get together for a game of "Musical ABC". Also on the show is Philadelphian comedian Johnny Dark.
Bob Monkhouse brings the house down after forgetting to zip up his trousers. "You've never got this many laughs before!" says Des, as the audience are in hysterics. Also on the show is a 30-year-old fresh comic by the name of Jay Leno.
Des reminisces over the early days of showbusiness with Val Doonican, sharing laughs and song. Also appearing is Gemma Craven, while Seattle comedian George Miller makes his UK TV debut.
Des gets the chance to duet with Wonder Woman herself, Lynda Carter. Also appearing are sketch comedians Fisher and Staahl, and magician Paul Daniels - but will any of them let Des forget he's wearing a pink suit?
Des introduces an unknown young comic who tells him he once had ambitions to be an actor: Michael Keaton. However, unseen technical issues cause Max Bygraves to come out with a fake beard: "I was clean shaven when this show started."
Bernie Winters tells Des about all the nervous failings he's made in the presence of Royalty, and how he's enjoying life as a solo act. Also appearing are singer Grace Kennedy and Chicago comedian Jimmy Aleck.
Des welcomes back Kelly Monteith for the third time, but a Kelly now with his own BBC2 show. Also appearing are the Three Degrees, while Des is in helpless hysterics at the nonsensical ramblings of Les Dawson.
Ventriloquism gets showcased in the last episode of the fourth series, as Norman Collier introduces his new dummy "Billy", and Ken Dodd comes on with Dicky Mint. Also appearing is Mimi Hines with her bittersweet character "The Faded Lady".