Anne Marie, a member of the Newcastle crew, asks John and Chas for help in Mexico City -- bringing them close to the heart of the rising darkness; Zed is haunted by her past.
While in art class, Zed has a bizarre vision of snakes that lead her and John to a small town where a preacher has mysteriously gained the ability to heal his congregation.
When Constantine's old friend Gary Lester accidentally releases a powerful demon in Atlanta, John is forced to determine exactly what he is prepared to sacrifice in his battle with the underworld.
When a young boy is taken over by a malevolent spirit, John must put aside his misgivings over exorcising a child and convince the parents that their boy is not all that he seems.
John is sent to help an old friend at Ivy University, where students have figured out how to get to an alternate dimension - only to be met by a killer.
In New Orleans, Constantine's unusual knowledge of a string of crimes gets him into trouble with Detective Jim Corrigan. He must form an unholy alliance with Papa Midnite when a voodoo ritual to help people communicate with their dead loved ones takes a deadly turn.
John and Zed return to New Orleans when Detective Jim Corrigan asks for their help in the case of a missing girl. Papa Midnite takes steps toward exacting his revenge on John. Meanwhile, the truth behind the Rising Darkness comes to light.