One scene in the game parodies the movie's ending if the player chooses to leave town immediatelly after arriving there. A kid calls the protagonist Shane and asks him to come back, to which the protagonist replies by shooting him and saying that he's not Shane.
When the protagonist meets the Man With No Name character and tries to shoot him, the Clint Eastood-looking Man With No Name pulls his gun first and shoots the protagonist, blowing his head clean off, just like the introductory narration about the awesome power of Dirty Harry's Magnum 44 revolver in the movie states.
If the protagonist is killed, the camera rushes to his grave using the deadite p.o.v. (point of view) from the movie, and sounds of deadites from the film can be heard. Also, the main villain is called Evil Eb.
The transition screen is the same as the one from the movie. Also, a the train the protagonist arrives on flies away if the player chooses to leave town immediatelly after arriving there. Also, the depiction of the protagonist on the game's cover art makes him look like Marty McFly in his western outfit.