While the cause of the Megaconda being freed from its nest is postulated multiple times as a Limnic Eruption, limnic (CO2) eruptions occur solely in lakes, which appears to be in short supply at the desert region the movie takes place in.
Having raised and cared for multiple snakes, one thing they all have in common is a slow digestive system. No snake eats any prey repeatedly the way the Megaconda does, with the sole exception of those snakes which eat insects, and even then they stop when they're 'full'
In the first 1.5 minute to 1.75 minute mark, the little loader changes from one with black fenders - no brand, to a fender less John Deere.
The sheriff is carrying a semi auto pistol as a sidearm. But instead of the necessary magazines in pouches, his spare ammo is revolver rounds in cowboy loops, and more revolver ammo in speed loaders .
At 49:29 Andy says "great" except his lips don't move and neither does his Adams Apple.
At 44:22 Anna appears to be ale to fire 7 shots (by the sound of it) from a six hot revolver. And again at 45:08 another seven rounds fired, despite no apparent reloads being carried, since she didn't even have a holster for the pistol.