The series is geared towards fans of the original show and features more mature content, which is why it airs on Paramount+ and not Nickelodeon.
Jennette McCurdy confirmed on her podcast in February 2021 that she has quit acting to focus on writing and directing and won't be appearing in the revival. She revealed that she never really liked acting and is embarrassed by the roles she played, including on iCarly (2007). It can be assumed that her character Sam Puckett was still living in L.A. as seen in the spin-off Sam & Cat.
Although Dan Schneider is credited as creator, he is not involved with the show.
Mia Serafino (Pearl) and Miranda Cosgrove (Carly) previously starred on the sitcom Crowded as sisters.