Title borrows from circumstances of Jesus' birth described in the Bible: "And she brought forth her firstborn son, and wrapped him in swaddling clothes, and laid him in a manger; because there was no room for them in the inn." (Luke 2:7)
Aunt Effie's last name is given as Crowley (Mama's maiden name), her and Mama's relationship revealed as that of cousins. In a later episode, Effie's last name is Harper (Mama's married name) and Mama refers to her as a sister-in-law. This seeming discrepancy could be resolved as follows: Effie Crowley, born to one of Mama's father's brothers, married a brother of Mama's husband Carl Harper, making Effie also Mama's sister-in-law.