The film required 2.8 tons of Plasticine in 42 colors and 1000 baby-wipes per week to wipe it off animators' fingers.
During filming, Aardman managed an average of 3 seconds of usable footage per day.
The film took five years to make. Production started shortly after the release of Chicken Run (2000), Aardman Studio's previous co-production with DreamWorks Animation.
DreamWorks wanted Aardman to replace Peter Sallis, the voice of Wallace since the first animated short, with a well-known actor that American audiences would recognize. According to Entertainment Weekly, they politely but firmly refused; instead, they got Ralph Fiennes and Helena Bonham Carter to play roles.
Nick Park and Steve Box referred to Wallace & Gromit: The Curse of the Were-Rabbit (2005) as the world's first vegetarian horror film.