The last movie Alan Alda directed. In a 2016 interview with podcaster Marc Maron, Alda indicated he didn't enjoy directing Betsy's Wedding, adding, "I didn't have fun." When Maron asked why, Alda declined to elaborate, saying "Never mind." He goes on to say "A young director once said of an actor he didn't like working with 'Was he hard to work with?' 'I don't remember'".
Correction to earlier trivia note: Joe Pesci and Catherine O'Hara play a married couple in this movie and have a handful of scenes together. However in their next film Home Alone (1990) they do in fact share one scene together and have a brief dialogue exchange which takes place at the beginning of the film.
Catherine O'Hara and Joe Pesci appeared in Home Alone (1990) and Home Alone 2: Lost in New York (1992) (shared no scenes). In addition, Ally Sheedy appeared in Home Alone 2: Lost in New York.