- She is the Muscular Dystrophy Association's National ALS Ambassador. Her mother, Betty, died from ALS in 2008.
- Met her husband (now ex-husband), Keith Zubulevich, in an airport security line.
- Her aunt, Ellen, has Down's Syndome. She is an inspiration to Nancy.
- First met friend, Maria Shriver, in 1993 thru "Best Buddies", an organization started by Maria's brother, Anthony Shriver. First heard of the program in Miami, where Nancy was a reporter.
- Is a sister of Kappa Kappa Gamma.
- Graduated as valedictorian from the now-closed Coastal Academy High School in 1984. She went on to graduate from Clemson University, summa cum laude, with a major in marketing in 1990.
- National spokesperson for the March of Dimes. Her mother, Betty, died from Lou Gehrig's disease three days before Ashby's first birthday.
- Launching an outdoor furniture line, Red Carpet Furniture, which will hit stores this spring. (May 2010)
- Release of her parenting book, "Full of Life: Mom-to-Mom Tips I Wish Someone Had Told Me When I Was Pregnant". (April 2009)
- Was in the same major (Marketing) and sorority (Kappa Kappa Gamma) as The Speed Report (1996)'s Connie LeGrand at Clemson University (1989).
- Stepson Tyler was born in 1996. Stepson Carson was born in 2000.
- Born in Sumter, South Carolina and moved to Myrtle Beach at the age of six months.
- Longtime friend of John Salley.
- Received an honorary doctorate from her alma mater Clemson University [May 13, 2013].
- Has a daughter, Ashby Grace Zubulevich (b. June 11, 2007 at Cedars-Sinai Medical Center in Los Angeles), with her ex-husband Keith Zubulevich.
- Friend of Lisa Rinna and Halle Berry.
- Miss South Carolina 1987 and represented the state at Miss America 1988, but did not place.
- Is a confessed Ping-Pong addict. She especially enjoys playing strip Ping-Pong.
- Ex-husband, Richard O'Dell, is a doctor.
- Named as Mary Hart's replacement on Entertainment Tonight (1981) after Mary leaves at the end of the season [November 9, 2010].
- Called her grandfather "Poppy".
- Hosting Access Hollywood (1996) with Billy Bush. (December 2006)
- (November 22, 2017) Her husband 12 years Keith Zubulevich filed for divorce from her following a year-long estrangement.
- Has left Entertainment Tonight (1981) [August 1, 2019].
- Placed first runner-up at Miss South Carolina USA 1990.
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