- The outfit she wore to the Oscars in 2010, the year she won for Best Supporting Actress, was inspired by what Hattie McDaniel, the first African-American Oscar winner, wore to the Oscar ceremony in 1940, the year in which she also won for Best Supporting Actress.
- Is one of 15 actresses to win the Critic's Choice Award, Golden Globe, Screen Actors Guild, BAFTA, and Oscar in the same year, winning for Precious (2009). The others to achieve this are Julia Roberts for Erin Brockovich (2000), Renée Zellweger for Cold Mountain (2003), Reese Witherspoon for Walk the Line (2005), Helen Mirren for The Queen (2006), Jennifer Hudson for Dreamgirls (2006), Kate Winslet for The Reader (2008), Natalie Portman for Black Swan (2010), Octavia Spencer for The Help (2011), Anne Hathaway for Les Misérables (2012), Cate Blanchett for Blue Jasmine (2013), Patricia Arquette for Boyhood (2014), Julianne Moore for Still Alice (2014), Allison Janney for I, Tonya (2017) and Frances McDormand for Three Billboards Outside Ebbing, Missouri (2017).
- Brother Gerald Imes publicly apologized to her on The Oprah Winfrey Show (1986) for molesting his sister when they were children. He revealed during his appearance that he himself was molested and was drinking alcohol and using drugs by the time he was 11 and that he started to molest Mo'Nique when he was 13 and she was 7/8 for about a year.
- Has 4 sons: Mark Eric Jackson Jr. (b. October 1990) & Shalon Calvin Jackson (b. June 1992) with ex-husband, Mark Jackson and David & Jonathan Hicks (b. October 3, 2005) with husband, Sidney Hicks.
- Gave birth to twin boys (her third and fourth child) at age 37, Jonathan Hicks and David Hicks on October 3, 2005. Children's father is her boyfriend [now second husband], Sidney Hicks.
- Is one of 7 African-American actresses to win the Oscar in a competitive category. The others in chronological order are Hattie McDaniel for Gone with the Wind (1939), Whoopi Goldberg for Ghost (1990), Halle Berry for Monster's Ball (2001), Jennifer Hudson for Dreamgirls (2006), Octavia Spencer for The Help (2011) and Viola Davis for Fences (2016).
- Launched own line of clothing Mo'Nique's Big Beautiful and Loving It in August 2000. It closed in 2002.
- Mo'Nique is the fourth talk show host to get an acting Oscar nomination after Oprah Winfrey (Best Supporting Actress; The Color Purple (1985), Whoopi Goldberg (Best Actress; The Color Purple (1985)(Best Supporting Actress; Ghost (1990)) and Greg Kinnear (Best Supporting Actor; As Good as It Gets (1997)).
- Won 30 major awards for her portrayal of Mary in Precious (2009), including all the awards that are considered the biggest (except Cannes). She was also nominated for 5 more awards for the same film.
- Release of her book, "Skinny Cooks Can't Be Trusted" by Mo'Nique with Sherri A. McGee (as Sherri A. McCovey). (2006)
- Release of her book, "Skinny Women Are Evil: Notes of a Big Girl in a Small-Minded World" by Mo'Nique with Sherri A. McGee. (2003)
- Mo' Nique stepped down as co-host of the morning show on WHUR Radio in Washington, DC during the Summer 2002.
- Daughter of Steven Imes Jr. and Alice Imes.
- Was the 135th actress to receive an Academy Award; she won the Best Supporting Actress Oscar for Precious (2009) at The 82nd Annual Academy Awards (2010) on March 7, 2010.
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