- He was the first artist for Marvel Comics' Spider-Man and his tenure is still the most influential creative period for the character which saw the creation of most of the classic supporting characters like J. Jonah Jameson and Aunt May, and villians like Dr. Octopus and the Green Goblin.
- Has created characters like the 1960s Blue Beetle, Captain Atom, Nightshade and the Question for Charlton Comics (now owned by DC Comics).
- Also created characters such Mr. A and Static which he owns personally.
- (1968 - 1980) Co-created major characters for DC Comics including The Creeper, Hawk and Dove, Shade: The Changing Man and the second Starman. He worked with Don Segall, Steve Skeates, Michael Fleisher and Paul Levitz on these respective titles.
- Created Doctor Strange for Marvel Comics.
- (1966-7) Drew stories for the Get Smart comic book for Dell Comics.
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