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- CreatorCarter BaysCraig ThomasStarsJosh RadnorJason SegelCobie SmuldersA father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.
- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorScott SilveriStarsMatthew PerryLaura BenantiJulie WhitePressured by his boss to join a support group because he can't move forward after his wife's death, an irreverent sportscaster finds connection with the extremely varied members.
- CreatorWhitney CummingsMichael Patrick KingStarsKat DenningsBeth BehrsGarrett MorrisTwo young women waitressing at a greasy spoon diner strike up an unlikely friendship in the hopes of launching a successful business - if only they can raise the cash.
- CreatorDarren StarStarsSarah Jessica ParkerKim CattrallKristin DavisFour female New Yorkers gossip about their sex lives (or lack thereof) and find new ways to deal with being a woman in the late 1990s.
- CreatorTina FeyStarsTina FeyAlec BaldwinTracy MorganLiz Lemon, head writer of the sketch-comedy show "TGS with Tracy Jordan", must deal with an arrogant new boss and a crazy new star while trying to run a successful television show without losing her mind.
- CreatorDavid AngellPeter CaseyDavid LeeStarsKelsey GrammerJane LeevesDavid Hyde PierceDr. Frasier Crane moves back to his hometown of Seattle, where he lives with his father and works as a radio psychiatrist.
- CreatorJimmy FallonCharlie GrandyAmy OzolsStarsAnthony AndersonJesse BradfordZach CreggerThree 30-something dads struggle as parents because they are still children at heart.
- CreatorGemma BakerEddie GorodetskyChuck LorreStarsAllison JanneyAnna FarisMimi KennedyA newly sober single mom tries to pull her life together in Napa Valley while dealing with her wayward mother.
- CreatorTom HertzStarsPatrick WarburtonMegyn PriceOliver HudsonTwo couples and their single friend, all at different stages in their relationships, deal with the complications of dating, commitment, and marriage.
- CreatorCarter BaysChris HarrisCraig ThomasStarsBecki NewtonScott FoleyMelissa TangThree estranged siblings are brought together once again at their father's funeral. His last will states that they must bond as a family via games thought up by their late father or they won't inherit the $23 million he has left them.
- CreatorRob GreenbergStarsKal PennJerry O'ConnellTony ShalhoubA young guy finds camaraderie living among the more experienced guys he meets in a short-term rental complex.
- CreatorMike SikowitzStarsMike O'MalleyMary McCormackJustina MachadoChronicles how cultures collide when a white family and a Latino family are bonded together by their children who fall in love followed quickly by an unplanned pregnancy.
- CreatorDavid KohanMax MutchnickStarsEric McCormackDebra MessingMegan MullallyGay lawyer Will and straight interior designer Grace share a New York City apartment. Their best friends are gleeful and proud gay Jack and charismatic, filthy-rich, amoral socialite Karen.
- CreatorLee AronsohnChuck LorreStarsJon CryerAshton KutcherAngus T. JonesA hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.
- CreatorEmily HalpernSarah HaskinsStarsMalin AkermanBradley WhitfordMichaela WatkinsA reformed party girl finds herself an insta-family after falling in love with a man with three manipulative children and two judgmental ex-wives.
- CreatorGregory Thomas GarciaStarsJ.B. SmooveMargo MartindaleWill ArnettA divorced reporter, looking forward to the single life, finds his parents' marital problems derail his plans.
- CreatorEileen HeislerDeAnn HelineStarsPatricia HeatonNeil FlynnCharlie McDermottThe daily mishaps of a married woman and her semi-dysfunctional family and their attempts to survive life in general in the town of Orson, Indiana.
- CreatorMark ReismanStarsDonald FaisonWayne KnightDavid Alan BascheA group of divorced friends tries to get back to the single life.
- CreatorChuck LorreBill PradyStarsJohnny GaleckiJim ParsonsKaley CuocoAspiring film actress Penny Teller moves into a Pasadena apartment across the hall from brilliant, but socially awkward, physicists Sheldon Cooper and Leonard Hofstadter and shows them how little they know about life outside of the lab.
- CreatorRebel WilsonStarsRebel WilsonKevin BishopLiza LapiraThree nerdy female friends decide to have super fun every Friday night.
- CreatorMark FarrellJoseph RasoStarsAdam KorsonCarrie-Lynn NealesAmanda BrugelSEED follows Harry, a likable bachelor and bartender whose previous foray into sperm donation has resulted in offspring he was unaware of - until now.
- CreatorSteven LevitanChristopher LloydStarsEd O'NeillSofía VergaraJulie BowenThree different, but related, families face trials and tribulations in their own uniquely comedic ways.
- CreatorJon LucasScott MooreStarsAdam CampbellAdan CantoAlexis CarraChronicles the exploits of singles, five guys and five girls, in search of love all over the course of one night.
- CreatorMark RobertsStarsBilly GardellMelissa McCarthyReno WilsonA couple meets at an Overeaters' Anonymous meeting.