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1-50 of 75
- The cases of rugged young Dr. Locke and his crusty mentor Dr. Sellers.
- Josie, daughter of prominent banker Sam Macklin, is found beaten and accusations flow as to who is responsible. Town tough Ned is jailed but further investigation by Dr. Locke reveal a young man Henny is suffering from severe headaches and blackouts. After Henny disappears, Ned's help is needed.
- Frank is a veteran beat cop who Dr. Locke discovers is slowly being poisoned after he collapses. The two team up to discover who is behind the attempt and why. The return of a drug kingpin may provide the answer.
- A lunatic is calling in false medical emergencies and killing the paramedics that respond. After losing his last partner, Dr. Locke is assigned Andrea, a colleague he formerly dated. Simon becomes overprotective but she insists she can do the job. The killer shows no partiality.
- Insurance agent Ben Grover stumbles onto a lucrative scam his bosses are using to steal from the company. Before he acts on it, an assassin is used to take him out, but they manage to only kill his wife instead. Grover then turns the tables seeking a deadly revenge.
- Detective Richard Gar is accused of being a dirty cop in a mobster's memoir. He declares his innocence to Dr. Locke who believes him. But his actions to clear his name go too far.
- Tom Fairly holds a compensation board captive after they decide his father's life was worth only fifty dollars. Dr. Locke becomes part of the situation when he arrives to treat a hostage, putting his own life at risk.
- Lt. Dan helicopters Dr. Locke to the home of Helen and Dave because the husband starts having a heart attack during a quarrel. In the air Dan learns a dangerous criminal has escaped and is later wounded by the convict. Dr. Locke is determined to save the husband and his friend while Dan is resolute that a killer must be recaptured.
- Bill, a former resident of Dixion Mills, comes back to town after receiving a terminal diagnosis. Dr. Locke is concerned about his actions and is adamant he deal with reality. The sheriff must locate an older man with a rifle who has been angered by his abusive business partner.
- While transporting a prisoner Dr. Simon Locke is poisoned Lt. Palmer is desperate to learn the type to provide an antidote. He focuses on criminal Duncan but when he's shot Palmer must look to someone he's close to.
- Bill Grady is a exceptional hockey player but drugs and a gambling syndicate have their hold on him. Dr. Locke discovers his hidden addiction and after convincing a protective brother Ed of the situation, they take drastic action.
- A mental block afflicts a museum guard who was the sole witness to a murder.
- Dr. Simon Locke is called to treat a severely beaten woman. Persistent questioning by the physician reveals that Phyllis and Delbert are siblings who run a badger scheme. Their current target is a local politician who doesn't take kindly to being blackmailed.
- Ed Morgan runs a construction business and has several near fatal "accidents". Dr. Locke patches him up but is determined to get to the source of the problem. Ed wants out of a syndicate smuggling opration but they consider him essential.
- Police Officer Mac Houston is traumatized when his partner is murdered and Dr. Locke is assigned to observe him to see if he's fit for active duty. While on patrol they encounter the killer and Locke gets his answer.
- After a party, a millionaire's mansion is invaded and his prize painting is stolen, and a guard is wounded. His neglected wife turns out to have organized it as a prank, but it has spiraled out of control when the thief is determined to collect ransom.
- Lt. Dan Palmer enlists Dr. Locke's help in exposing a nightclub that is a front for a lucrative drug trade. The doctor is also intrigued by an attractive singer at the bar.
- A politician witnesses a mob murder but lets his mistress Nora tell the police she saw it. Dr. Locke becomes involved after he says she has a medical condition to make that impossible but a hitman still goes after her.
- Dr. Simon Locke treats an extortionist Paul Shaver after he is shot. When he once again evades conviction, Simon works to have him brought to justice. Shaver's girlfriend Arline may provide the crucial information.
- A stolen cache of heroin puts Dr. Simon Locke on the trail of a missing police sergeant.
- James Blinn's attempt to rob a record store goes awry when the proprietor suffers a heart attack. He takes a customer hostage along with Dr. Locke who enters the store to give medical attention.
- Dr. Sellers runs into Ellen Hewitt, an old flame, in the city and she accompanies him back to Dixion Mills. But after she had a medical examine with Dr. Locke, he has unfortunate news to deliver.
- After a bitter custody dispute, Jeff, a mute boy, is placed in his father Burt's care instead of his mother Stella. He climbs the town water tower in the middle of winter in protest, drawing Dr. Sellers and Dr. Locke into the situation.
- Dr. Sellers and Dr. Locke decide to prepare a patient for delicate heart surgery after some debate. But their task is interrupted when two bank robbers take them hostage.