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- A team of exceptional forensic pathologists and scientists investigate heinous crimes and use their skills to catch the people responsible.
- Scotland Yard Commander Adam Dalgliesh has been on leave following the death on duty of a member of his team, DS Sarah Hillier. His superiors order him back to work to investigate the murder of the Director of the Steen Clinic, which specializes in psychiatric cases. Dalgliesh and his team can't quite figure out why they've been assigned to what seems to be a straightforward murder case but it's clear that his superiors want him to get in and out as quickly as possible. There is any number of possible suspects and as Dalgliesh is fond to say, the motive for murder is inevitably greed or love.
- In a world overtaken by eternal darkness, the buttoned down entomologist abandons his phantoms to embrace the unknown. Oscar is a conservator at the Natural Science Museum, and spends most of his days surrounded by bugs. When Oscar isn't tending to the tiny specimens that line his home and workplace, he can frequently be found reflecting on his childhood traumas in the psychiatrist's office. One day, Oscar returns home from work to find an African woman from the museum lying in his bed.
- Mars suffers daily and never has a chance. While he is in a strip bar he falls in love with the Russian Sophia, whose son Sasha is being held by the Mafia.
- A classical musician demands that his beautiful daughter and his young son follow in his footsteps despite their personal wishes.
- 1996–20071h 30mTV-147.5 (203)TV EpisodeWhen the body of a school principal, thought to be buried in Austria, is found under her own memorial in the school grounds, police detectives Andrew Dalziel and Peter Pascoe are called in to piece together the circumstances surrounding her untimely death.
- When Mark James' decomposing body is found in an abandoned building, there is every indication that he was part of some occult ritual. An upside down cross was carved on his chest, his wrists were bound with ivy and he was strangled. All evidence points to his friend Sebastian Bird, a rich idler who allowed James to live in his house but who had also developed a expert knowledge of the occult before being sent down from Cambridge for having had an affair with a professor's wife. Sam Ryan's testy relationship with the police continues as she is having difficulty establishing a forensic link in the case and also for publicly criticizing the well-liked Police Surgeon, Dr. Richard Owen, for attending the crime scene without the proper protective clothing. Sam also has to deal with her rebellious nephew Ricky, who is constantly fighting with his mother and announces that he has left home to move in with her.
- When a dozen people die in a cinema fire, Connor is in charge of the investigation. Sam Ryan is coming back to Cambridge.
- Sam Ryan takes on a gangland murder case to help builder Brian McNally, whom she believes to be innocent.
- The team is called out to Northern Ireland to investigate the bodies of two men killed by paramilitaries twenty years ago. For Sam, it is a case that is soon to turn personal.
- Sam is shaken when she has to look into the death of a very dear friend, Dr. Annabelle Evans, a Cambridge professor. She was found in her home, badly beaten in what appears to be a botched burglary attempt. The police immediately focus on the husband as the likely killer but Sam suspects that an altercation at a local restaurant during the May Ball, where a waiter spilled wine on Annabelle and was fired on the spot, may provide another suspect. Sam is also intrigued by the relationship some of her students may have had with Annabelle, particularly when she learns her friend may have had a lover. In her personal life, Sam has moved on. Her sister Wyn has relocated to Ireland and Peter Ross has also been transferred. She does however run into an old friend who also happens to be an acquaintance of her business partner Trevor.
- In a suspected terrorist attack on a London hotel a government minister is killed. As Sam and the team investigate the case, old friends and government officials soon muddy the water.
- Questions about a celebrated pathologist's accuracy in past cases leads to several exhumations; Sam Ryan is assigned to reexamine the remains. One particularly brutal murder conviction depends on the time of death being precise. Two crucial witnesses are found: one on her deathbed, anxious to get something off her chest, and the other dead behind a remodeled wall.
- Boxer Kevin Sharma dies from blows received in the ring, but pathologist Sam Ryan determines that he has a brain injury dating from sometime after his last bout two months ago. One of the governors of the boxing board, retired police Superintendent Jack Reeve, is concerned that it will reflect badly on them. Reeve is also trying to cancel one-time trainer Terence Cross' license after he is the victim of a hit and run accident that leaves him a quadriplegic. A new Detective Superintendent, Peter Ross, is now in charge and Sam and he knew each other many years previously. Trevor finds himself alone after his wife leaves him. Sam and her sister Wyn bury their mother
- The team investigates the derailment of a train caused by someone leaving Maj. Mark Wiltshire's Land Rover on the tracks. The army is suspected but Wiltshire was in the officers mess at the time. The team have yet to identify the 21st victim, or determine if that person was on the train or in the car. Working with a survivor's group, they try to re-create where everyone was seated just prior to the crash occurring. When one of the survivors commits suicide, the crash claims its 22nd victim.
- When Philip Nelson is killed in a farm accident, the pathologists conclude they have a straightforward case of man vs. machine and the machine won. Sam makes an error however and soon finds evidence that points to murder. The police suspect his handyman, all the more so when they discover he was having an affair with Nelson's wife. When the murders continue however, Sam uncovers evidence that connect at least some of the men to events in Northern Ireland when they served in the army together many years before. Sam is more than a little surprised when Charlie, an old friend, sounds her out about taking up a new Chair in Forensic Pathology at London University. DI Michael Connor and his wife take a stab at a reconciliation but he finds it difficult to forgive her infidelity and realizes he has feelings for Sam.
- Forensic pathologist Dr. Sam Ryan returns to Cambridge to take up a teaching assignment and to work for the police as required. In her first case, she has to deal with the death of a six year old girl find floating in a nearby river. The autopsy reveals that the child has suffered previous abuse, including cigarette burns and several broken ribs. Sam receives information from a prison inmate that implicates someone in a previous death and Sam suggests a radical step. In her personal life, Sam has to deal with her elderly mother who is showing signs of dementia and her sister Wyn with whom she has a strained relationship.
- When a boat carrying illegal passengers is found crashed in the Thames, the team investigate.
- The team follows the trail of the people traffickers, and has to find any remaining survivors before a highly contagious disease breaks.
- Stuart Evans is 40 years old and in the advanced stages of AIDS. When he dies the night after his birthday party no one thinks anything of it but his parents donate his remains to scientific study. When Sam and Trevor start an examination of the remains, they notice needle marks and suspect his death may not have been straightforward. Their suspicions are confirmed when the toxicology reports indicate an extremely high level of morphine. Mark Tate is also an AIDS sufferer who has been told that he will soon go blind. He too dies suddenly and when the police learn that he and Evans had the same physician, they begin to suspect doctor-assisted suicide.
- The team is called to a drive-by shooting outside a London nightclub. They arrive to a scene of carnage with several people dead, or dying.
- The police may have a serial killer on their hands when they locate a second body in a site where the first victim was found several months before. The body was trussed up in the same way and had an identical burn mark on his back. There is no apparent link between the first victim, student Michael Haughty, and the second Jason Villers, a probationer at the police college. While the police find evidence that may solve the Otty case, they have nothing on the Villers murder. In a separate case, Harry is approached by the wife of an old university friend who asks him to perform a post-mortem on her husband who died in a fall. Harry finds that his old friend was injecting himself regularly. Leo's family is visiting for a few days but he's constantly being called into work.
- Sam investigates the death of a gay man while in police custody. He had been arrested while drunk and was sharing a cell with another drunk, in for the night. The victim died from a blow to the head and was badly beaten post-mortem. DS Farmer is concerned that the assault may have been the work of some of her officers. Sam also meets up with Liam Slattery an old friend she has not seen for 20 years. Sam's sister however is convinced Liam was responsible for the death of their father years before.
- Tensions are running high in the 'leaderless' team as Leo and Harry clash over an investigation into an outbreak of breathing difficulties among children on the South Coast.
- Sam Ryan looks into the death of Maggie Collins who died of a heroin overdose. Sadly, her body wasn't discovered for several days and in that time, her infant daughter died of dehydration. Soon after Maggie's death Stephen Jackson, a small-time dealer and addict, is killed in an explosion in his home. The autopsy reveals that both of them died of overdoses from the same batch of heroin and Sam begins to doubt that their deaths were accidental. When another small-time dealer is killed, the police think they have either vigilantes or a turf war on their hands. What they have is something far more complex that involves one of their own.
- Sam Ryan is under great stress when she learns that she may have a tumor. As a result, she starts to question her judgment when she misses a possible explanation in determining the time of death in the case of Lloyd Dupen's wife, an apparent suicide. She's not convinced however that everything is above board and agrees to undertake a second autopsy at the request of the dead woman's mother. She's also asked by Bishop Craig to perform an autopsy on the remains of Sister Constance, a beatified nun who died forty years ago and is under consideration for canonization. The results of the autopsy will have an impact on the religious order as well as many of those in the community who see the commercial advantages of having a local saint.
- Gemma Boyd, an attractive 17-yr old, is found dead at the bottom of a staircase. Although the cause of death was a broken neck, there is little to indicate whether she fell or was pushed. She was found in a vacant house that her estate agent mother and step-father were selling. The autopsy reveals that Gemma had already had a child and was pregnant. The police think that Gemma's boyfriend is their man but when someone else is revealed as the father in the latest pregnancy, Sam thinks there is a far more complex set of relationships at play. Sam's sister Wyn visits from Ireland with big news: she is going to get married. Sam's relationship with James however takes an unfortunate turn and seems to come to an end.
- Sam comes under intense scrutiny during an official inquiry into the deaths of two brothers while they were in prison. Her findings are soon challenged by her colleague, Leo Dalton, who is brought in to perform a second autopsy. Meanwhile, a series of murders that are taking place cast suspicion on a recently released ex-convict. He served years in prison after being convicted of killing his wife; the evidence against him was given by Sam during one of her very first cases. During his time in prison, however, he continued to deny his guilt. Sam begins to believe that someone is stalking her, while the police have trouble locating the ex-convict.
- When 72-year old Millicent Lockwood is found brutally beaten to death in a local park, the police immediately focus on a local who was seen arguing with her a short time earlier. The autopsy reveals little evidence but Sam Ryan once again refuses to make the evidence they do have fit the suspect, which leads to an inevitable clash with the police. She also sees two youths, Kelvin Price and Ben Quayle, act out part of the murder. The police however are pursuing other lines of inquiry and don't have the time, nor the inclination, to pursue Sam's theories. She then sets off on her own investigation.
- The team is shocked when Leo Dalton's wife and daughter are killed when a fancy sports car careens out of control and smashes into a café. The police are puzzled by the cause of the crash but believe the driver may have been involved in a identity theft ring when they find several several passports and ID cards in the vehicle. Meanwhile, Nikki must perform urgent autopsies on two bodies found floating in the river. When she finds fingerprint evidence linking one of the bodies to the car accident, it becomes apparent that the two cases are linked and the police may have been less than forthcoming about their investigation.
- After a helicopter sends out a mayday and disappears in a storm en route to provide support to an off-shore oil rig, Sam is called upon to participate on the rescue team in case it turns into a recovery team.
- The police investigate an apparent break-in that results in the death of Derek Irons, his wife and youngest daughter. Two older children survived the attack but one is in serious condition and in a coma. Irons was a ruthless businessman who targeted his rivals' customers resulting in regular confrontations. Irons was stabbed but his wife and daughter were shot. Sam is reunited with an old friend from Northern Ireland, Det. Supt. Tony Ashton who is the senior investigative officer on the case. Harry assists the police with the death of an old woman who is believed to have fallen down a staircase. His post-mortem reveals evidence that is not consistent with a fall.
- The team investigates two deaths, the first a suicide where someone jumped to their death and the second where a paranoid schizophrenic dressed as a vicar goes on a rampage stabbing innocent bystanders. Their suspicions are aroused when they learn that both men were receiving treatment at the same clinic, January House. Leo assists the police in their investigation of a building society employee who is forcibly taken from his house and subsequently found dead in his own car. Harry is asked to perform an autopsy and provide a second opinion in the death of a young woman. The death was ruled a suicide, but the mother refuses to accept the verdict.
- Harry is called out to a death at a racecourse. A jockey was killed when his horse pulled up and fell, crushing him to death.
- Helen Mathews is found strangled on the street. In the course of the investigation, the police learn that she was having an affair with Alan White, a flying instructor working for her husband Michael. From the evidence, it appears that she was about to leave her husband and move to Canada. The police uncover a similar case from several years earlier with a striking resemblance to this case and are convinced that the two must be connected. Friction again develops between Sam Ryan and the police when her forensic analysis demonstrates that the two cases have no connection whatsoever. Sam continues to fret over her decisions in her last case and her personal relationship with Peter Ross reaches a breaking point.
- A John Doe is found months after his death; an attractive female agent for a championship athlete is believed to have jumped to her death from a rooftop. Forensic pathologists must sort out time and methods of death.
- One of Sam Ryan's students has a problem and seeks some personal advice. She and her family immigrated from Vietnam during the boat people exodus and her father wants her to enter a marriage he's arranged for her. She's worried that her husband to be will realize she is not a virgin and Sam counsels her that honesty is always the best policy, but in this case it drives the prospective groom to violence. When the family's restaurant is burned out, the police find a badly burned body. On the home front, Sam continues to bicker with her sister Wyn about whether their mother should be placed in a home and the bitterness over their father's death continues to divide them.
- When a decomposed body is found hidden in the wall of an old factory building, Sam Ryan concludes he was murdered. He is eventually identified by his ex-girlfriend Selina Thomson as Marcus Saul, who had simply disappeared one day some seven years earlier. There has also been a break-in on campus and drugs have been stolen. The Dean asks Leo Dalton to speak to some of the students on the issue, but he's not quite sure what he can do.
- Sam Ryan assists the police in the investigation of a multi-vehicle collision that results in the death of 11 people. She is joined by two new colleagues: Dr. Leo Dalton, an experienced pathologist from Sheffield and Dr. Harry Cunningham. As they try to determine the causes of the accident, they find a severed arm that does not belong to any of the victims. They also have to deal with DCI Carol Deacon whose role in the investigation is not quite clear to them. Sam and Leo have somewhat different approaches to their job, particularly in how they deal with the police. Harry performs his first autopsy on a child.
- Harry investigates the death of a woman who drowned in a backyard pool. She was apparently struck on the side of the head and her husband claims that her expensive necklace is missing. Leo and Nikki investigate the death of Lucie Philips, a kidnap victim who was taken a week previously. The girl's father tried to pay the ransom but the money was never collected leading the police to believe that the kidnappers may have had other motives. They also investigate the murder of a pizza deliveryman that has similarities with the Philips crime scene. A third murder leads the police to suspect that they may be seeing the work of a serial killer. Nikki's grandmother dies bringing her into contact with her estranged father.